CRS Scientist Spotlight on Dr. Jeff Pea

Jeff Pea, PhD, is the Scientific Lead for the Ovarian Contraceptive Discovery Initiative (OCDI), a multi-institutional program based in the Duncan Lab. The OCDI is focused on the exploration of ovarian biology to identify novel non-hormonal contraceptive targets for women.

What brought you to join the CRS community and what is your current position?  

I am currently the Scientific Lead for the Ovarian Contraceptive Discovery Initiative (OCDI), a multi-institutional program based in Dr. Francesca Duncan’s lab as well as three other partnering research groups. For me, I joined the CRS because it is a wonderful community filled with scientists and researchers enthusiastic about reproductive biology. When I first came here, I loved how there was a balance of interconnected yet unique projects happening across the center. I also enjoyed the collaborative nature of CRS, where everyone can ask for help and support each other! 

Could you describe what your work entails? 

The OCDI is focused on the exploration of ovarian biology to identify novel non-hormonal contraceptive targets for women. My work has many hats, but overall I help oversee and integrate the multiple research projects we have investigating different ovarian processes, including follicle activation, folliculogenesis, and ovulation, to identify new targets for contraception. We do so by combining two complementary approaches: (1) ex vivo ovarian cell-based assays to screen chemical compounds and (2) transcriptomic approaches to identify novel genes enriched during these ovarian processes. The goal is to identify new pathways or genes that can be targeted for a contraceptive effect without affecting hormone production. 

What aspect(s) of CRS do you find most valuable?  

To have a center solely focused on reproductive science is truly unique, so I really appreciate how CRS creates a space where many leading scientists and trainees can converge to discuss and support projects across the field. CRS also provides an excellent opportunity for basic scientist and clinicians to work together to work on translational studies that exemplify the “bench to bedside” approach. But what I really find most valuable is that the center is welcoming to all members, whether it is faculty, staff, or students, to share their ideas and uplift each other.  

What has been the most valuable aspect of your work in reproductive science? 

For me, the most valuable aspect of my work has been the mentorship and training of scientific trainees within the reproductive sciences. As projects evolve and change dramatically, what I have always appreciated was the opportunity to support new students and staff in various parts of their scientific training. Whether that is helping with designing experiments, interpreting their data, or communicating their work to others, I really enjoy teaching and mentoring others so that they can become well-rounded, independent researchers. 

What would you recommend to students and young professionals for them to succeed in their careers?  

I know this is always easier said than done, but I think it is important to sometimes take a step back and think about what “success” looks like for you. Many people will tell you what your “success” looks like, but that is really a personal question. What are things that you enjoy doing? What skills do you think you have or want to learn? For many people, their career path is not straightforward and it may feel like there are very limited options available. However, it can help to think about your career from a different perspective: regardless of your role, what responsibilities do you want? Is it hands-on research, teaching, mentorship, project management, communication, networking, and more? By considering what you may want to do within your role, you may find that there are more opportunities out there that fit your criteria. When I first started my graduate studies, the position I have now never existed. So always keep an open mind and explore what options are out there that may work best for you! For those that are still unsure, I always encourage people to try new things that may interest them. If you find someone whose work you find interesting, reach out to them! Explore new fields or opportunities that may not fully align with what you are doing currently. Even if they do not work out, these experiences will shape who you are along your journey and help guide you to what you truly want to do. Lastly, use your network! Whether it is your friends, mentors, lab members, or others within the CRS, these is a community that wants to support you and help you towards your next step.  

What do you think will be the next big contribution in the reproductive biology field?  

I am a little biased, but contraception (for both men and women). We are starting to see now increased investment, both academically and industry, to develop the relevant biological datasets and systems to specifically focus on contraceptive discovery. With that in mind, I think we are looking at a changing landscape where we may have more access and choice for individuals or couples seeking contraceptive options. These efforts would have major impacts in empowering women during family planning, especially in regions around the world that remains limited in options due to accessibility and cultural norms.  

What hobbies do you have outside of the lab?   

I love the outdoors (rain or shine) so you will always find me running by the lake, walking through Lincoln Park, or playing pickup soccer. I can also be found at the local museum, aquarium, zoo, etc.! Besides that, I enjoy spending my time cooking new recipes, watching movies, or doodling.